PDRN & Skin Regeneration:
The Science Behind Exosomal Skincare at Ten Spa and TenSkin Rx
At Ten Spa, we don’t chase trends—we chase results. And when it comes to real skin regeneration, skin science has caught up. Think: polynucleotides + synthetic exosomes. We're talking cellular-level repair in a delivery system that gets results.
Why Your Skin Stops Repairing Itself
Around age 18–25, your skin’s internal repair system starts to slow down. This decline starts with your body producing less hyaluronic acid (HA)—and that’s a bigger deal than it sounds.
HA isn’t just about hydration or glow. It’s the structure that holds your skin’s extracellular matrix together. It’s the fluid that allows cells to move, communicate, and rebuild. Without it, fibroblasts can’t migrate to injury sites, keratinocytes slow down, and collagen synthesis—your skin’s scaffolding—takes a nosedive. You can’t regenerate what you can’t stabilize. And that’s how we end up with slower healing, thinner skin, dullness, and a loss of elasticity. It’s not about surface damage—it’s about your skin losing its ability to bounce back from things like inflammation, UV exposure, hormonal fluctuations, and stress.
PDRN: DNA Fragments That Reboot Your Skin’s Repair System
Polynucleotides are small pieces of purified DNA—often derived from salmon—that act like blueprints for tissue repair. They stimulate fibroblasts (your collagen-producing powerhouses), support wound healing, and fight oxidative stress at a cellular level.
A specific type of polynucleotide, PDRN (polydeoxyribonucleotide), is especially powerful. It’s anti-inflammatory, promotes vascularization (which boosts nutrient delivery), and triggers collagen and elastin production. Essentially, it tells your skin to act young again.
But here’s the problem: polynucleotides on their own don’t always work. They’re large, fragile molecules that can struggle to penetrate the skin barrier. They often get blocked by structural proteins or break down before they reach their target. Sometimes, they even pull in too much water and cause puffiness.
The Game-Changer: Synthetic Exosomes as Smart Delivery Systems
This is where things get exciting. Synthetic exosomes are microscopic messengers designed to carry regenerative molecules—like polynucleotides and peptides—straight to the cells that need them.
Think of them as Amazon for your skin: they know exactly where to go, what to deliver, and how to get past all the roadblocks that usually stop skincare ingredients in their tracks. They don’t just sit on the surface and “plump” for a few hours—they enter the skin barrier, communicate with cells directly, and activate fibroblasts, encouraging them to produce collagen, elastin, and hyaluronic acid like they did when you were young.
Now, let’s address the elephant in the room: exosomes can also come from human or animal sources. But that’s not what we use. At Ten Spa and TenSkin Rx, we use synthetic exosomes—lab-created, completely uniform, and free of the risks associated with biologically sourced ones (like disease transmission or allergic reactions). Each millilitre of our exosomal serum contains over a billion perfectly engineered exosomes—stable, safe, and highly effective.
How to Integrate Exosomes Into Your Skincare Routine
We’re not just offering one way into the world of regenerative skincare—we’re giving you options. Whether you want to amplify your in-studio treatments or bring that science home with you, we’ve made exosomes accessible in three powerful formats:
🔬 Professional Add-On Treatment: V-Tech Exosomes at TenSkin Rx
Offered as an add-on to the advanced RF microneedling and YAG + IPL laser treatments, at TenSkin Rx, the V-Tech Exosome infusion is your go-to if you want real results, fast. This powerhouse blend features 2% polyribonucleotides, biomimetic peptides, and green apple stem cells, delivered via synthetic exosomes designed to penetrate deep into the dermis. It’s precision skincare with regenerative impact—perfect for post-procedure recovery, enhanced collagen stimulation, and long-term skin restructuring.
✨ Professional Add-On Treatment: Skin Boosters at TenSkin Rx
Looking for even more impact? TenSkin Rx Skin Boosters are high-performance, targeted serums that elevate any facial treatment with instant and lasting results. Add one to your next RF or laser appointment for a customized boost in skin function, tone, and radiance. Choose from: FIXER, WHITE IN, UP GRADE:
FIXER
A breakthrough alternative to botulinum toxin, FIXER features four potent actives that visibly reduce fine lines, soften deep wrinkles, and revive skin that’s lost its energy. It works by restoring tone and texture where your skin needs it most.
⭐️Reduces the appearance of moderate to deep wrinkles
⭐️Tones and revitalizes dull, atonic, or asphyxiated skin
WHITE IN
A brightening powerhouse, WHITE IN uses Arbutin and DMCP to target pigmentation caused by sun damage, inflammation, or hormones. It helps even out skin tone and fade stubborn spots over time.
⭐️Diminishes freckles, melasma, and age spots
⭐️Fades post-inflammatory hyperpigmentation and discoloration
UP GRADE
For clients dealing with dehydration, loss of elasticity, or signs of aging, UP GRADE is a go-to. This intensive hydrator uses a professional blend of hyaluronic acid, peptides, vitamins, and antioxidants to deeply regenerate skin at the cellular level.
⭐️Replenishes hydration in severely dry skin
⭐️Improves elasticity and fills depressions (including tear troughs)
⭐️Boosts collagen production and cell turnover
⭐️Fights oxidative stress to slow visible aging
Whether your goal is smoothing, brightening, plumping, or regenerating, Skin Boosters are the perfect complement to your exosome-enhanced treatment.
🧪 At-Home Recovery Mask: PromoItalia Exocell Mask
Post-treatment recovery just got an upgrade. The Exocell Mask by PromoItalia is our go-to for speeding up regeneration after any advanced facial treatment—microneedling, RF, peels, lasers, you name it. Priced at CA$550 for a box of 5 masks, this bio-cellulose powerhouse delivers clinical-grade hydration, cellular repair, and visible rejuvenation.
Made from medical-grade fermented plant fibers, the mask adheres to the skin like a second layer—locking in potent actives while creating the perfect environment for healing. It’s packed with low molecular weight polynucleotides, biomimetic peptides, hyaluronic acid, and natural antioxidants. Leave it on for 30–45 minutes—no rinse, no fuss, just high-performance recovery that works in sync with your skin.
💧 Daily Maintenance Serum: PromoItalia Exotech Gel
This is your everyday hero. Exotech Gel ($400 | 30 mL) brings the power of millions of synthetic exosomes into your daily routine—delivering polynucleotides, biomimetic peptides, snail mucin, and LMW hyaluronic acid straight to the cells that need them. Use it AM and PM to boost regeneration, tighten skin, and support long-term collagen synthesis.
Born from the research labs at VM Corporation, this formula is engineered to do more than just moisturize. It stimulates collagen, repairs damage, and restructures your skin on a cellular level—making it ideal for both everyday use and post-treatment recovery.
Whether you’re rebuilding your skin after treatment, maintaining results, or just ready to level up from “hydrated” to regenerated, exosomes are the future—and now, they’re finally easy to access.
Book your exosome add-on, or shop our new Exocell and Exotech formulas in-store or online.
Your skin’s next chapter starts here.
Sources:
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Shiekh, P. A., Singh, A., Kumar, A., & Mir, M. A. (2022). Exosome therapy in hair regeneration: A literature review of the evidence, challenges, and future opportunities. Journal of Cosmetic Dermatology, 21(2), 584–593. https://pubmed.ncbi.nlm.nih.gov/35441799/
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